The France international was forced off in the weekend win over Burnley, and Jose Mourinho has confirmed he will not be fit to take part at the Etihad Stadium tomorrow.
Antonio Valencia and Ander Herrera, however, are available for United in this crunch encounter against City in the battle for an all-important Premier League top four spot.
Pogba has been heavily involved for United this term (Picture: Getty)
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Speaking after the win over Burnley, Mourinho admitted he wasn’t sure what the problem with Pogba was, but suggested it could be down to exhaustion after playing so many games this season.
Pogba for club and country this season
‘If he is injured or it’s just super-accumulation of fatigue in the muscles, I don’t know.’
Chris Smalling and Phil Jones are also still out, with United facing a mini-crisis in defence as Marcos Rojo was recently ruled out for the rest of the season.
Zlatan Ibrahimovic is also out for the remainder of the campaign after suffering an anterior cruciate ligament injury in the recent win over Anderlecht.